Path ID: DB00356_MESH_D009128_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002753 | chlorzoxazone | Drug |
| MESH:D015220 | Calcium Channels | GeneFamily |
| MESH:D015221 | Potassium Channels | GeneFamily |
| GO:0016917 | GABA receptor activity | MolecularActivity |
| GO:0061534 | Gamma-aminobutyric acid secretion, neurotransmission | BiologicalProcess |
| GO:0090075 | relaxation of muscle | BiologicalProcess |
| GO:0006936 | muscle contraction | BiologicalProcess |
| HP:0031826 | Abnormal reflex | PhenotypicFeature |
| HP:0003394 | Muscle spasm | PhenotypicFeature |
| HP:0002493 | Upper motor neuron dysfunction | PhenotypicFeature |
| MESH:D009128 | Spasticity | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Chlorzoxazone | NEGATIVELY CORRELATED WITH | Upper Motor Neuron Dysfunction |
| Upper Motor Neuron Dysfunction | POSITIVELY CORRELATED WITH | Spasticity |
| Chlorzoxazone | DECREASES ABUNDANCE OF | Abnormal Reflex |
| Abnormal Reflex | POSITIVELY CORRELATED WITH | Muscle Spasm |
| Muscle Spasm | POSITIVELY CORRELATED WITH | Spasticity |
| Chlorzoxazone | NEGATIVELY REGULATES | Calcium Channels |
| Chlorzoxazone | NEGATIVELY REGULATES | Potassium Channels |
| Calcium Channels | POSITIVELY CORRELATED WITH | Muscle Contraction |
| Potassium Channels | POSITIVELY CORRELATED WITH | Muscle Contraction |
| Chlorzoxazone | POSITIVELY REGULATES | Gaba Receptor Activity |
| Gaba Receptor Activity | POSITIVELY CORRELATED WITH | Gamma-Aminobutyric Acid Secretion, Neurotransmission |
| Gamma-Aminobutyric Acid Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Relaxation Of Muscle |
| Muscle Contraction | POSITIVELY CORRELATED WITH | Spasticity |
| Relaxation Of Muscle | NEGATIVELY CORRELATED WITH | Spasticity |
Comment: Althouth InterPro and Pfam have entries to encompass different types of calcium channels, the chosen MESH term is the most generic term that encompasses ALL calcium channels, rather than individual domains, subunits or classes.
Reference: