Path ID: DB00354_MESH_D009041_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C046894 | Buclizine | Drug |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| UniProt:P11229 | Muscarinic acetylcholine receptor M1 | Protein |
| HP:0002017 | Nausea and vomiting | PhenotypicFeature |
| GO:0034776 | Response to histamine | BiologicalProcess |
| GO:1905144 | Response to acetylcholine | BiologicalProcess |
| MESH:D009041 | Motion sickness | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Buclizine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Buclizine | DECREASES ACTIVITY OF | Muscarinic Acetylcholine Receptor M1 |
| Histamine H1 Receptor | POSITIVELY REGULATES | Response To Histamine |
| Muscarinic Acetylcholine Receptor M1 | POSITIVELY REGULATES | Response To Acetylcholine |
| Response To Histamine | POSITIVELY REGULATES | Nausea And Vomiting |
| Response To Acetylcholine | POSITIVELY REGULATES | Nausea And Vomiting |
| Nausea And Vomiting | POSITIVELY CORRELATED WITH | Motion Sickness |
Reference: