Path ID: DB00352_MESH_D015470_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013866 | Thioguanine | Drug |
| CHEBI:80613 | 6-Thioguanosine monophosphate | ChemicalSubstance |
| UniProt:P00492 | Hypoxanthine-guanine phosphoribosyltransferase | Protein |
| UniProt:Q06203 | Amidophosphoribosyltransferase | Protein |
| InterPro:IPR005990 | Inosine-5’-monophosphate dehydrogenase | GeneFamily |
| MESH:D004247 | DNA | ChemicalSubstance |
| GO:0006164 | purine nucleotide biosynthetic process | BiologicalProcess |
| GO:0016049 | cell growth | BiologicalProcess |
| CL:0001063 | neoplastic cell | Cell |
| MESH:D015470 | Leukemia, Myeloid, Acute | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Thioguanine | HAS METABOLITE | 6-Thioguanosine Monophosphate |
| 6-Thioguanosine Monophosphate | DECREASES ACTIVITY OF | Hypoxanthine-Guanine Phosphoribosyltransferase |
| 6-Thioguanosine Monophosphate | DECREASES ACTIVITY OF | Amidophosphoribosyltransferase |
| 6-Thioguanosine Monophosphate | DECREASES ACTIVITY OF | Inosine-5’-Monophosphate Dehydrogenase |
| 6-Thioguanosine Monophosphate | DISRUPTS | Dna |
| Hypoxanthine-Guanine Phosphoribosyltransferase | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Amidophosphoribosyltransferase | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Inosine-5’-Monophosphate Dehydrogenase | POSITIVELY REGULATES | Purine Nucleotide Biosynthetic Process |
| Purine Nucleotide Biosynthetic Process | POSITIVELY CORRELATED WITH | Cell Growth |
| Dna | LOCATED IN | Neoplastic Cell |
| Cell Growth | OCCURS IN | Neoplastic Cell |
| Neoplastic Cell | CAUSES | Leukemia, Myeloid, Acute |
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