Path ID: DB00351_MESH_D016889_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008535 | megestrol acetate | Drug |
| UniProt:P06401 | Progesterone receptor | Protein |
| UniProt:P01148 | gonadotropin releasing hormone | Protein |
| GO:0032275 | Luteinizing hormone secretion | BiologicalProcess |
| GO:0035937 | estrogen secretion | BiologicalProcess |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| UBERON:0001295 | Endometrium | GrossAnatomicalStructure |
| MESH:D016889 | Endometrial carcinoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Megestrol Acetate | INCREASES ACTIVITY OF | Progesterone Receptor |
| Progesterone Receptor | DECREASES ABUNDANCE OF | Gonadotropin Releasing Hormone |
| Gonadotropin Releasing Hormone | POSITIVELY REGULATES | Luteinizing Hormone Secretion |
| Luteinizing Hormone Secretion | POSITIVELY REGULATES | Estrogen Secretion |
| Estrogen Secretion | POSITIVELY REGULATES | Cell Population Proliferation |
| Cell Population Proliferation | LOCATED IN | Endometrium |
| Endometrium | POSITIVELY CORRELATED WITH | Endometrial Carcinoma |
Reference: