Path ID: DB00350_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008914 | Minoxidil | Drug |
| UniProt:P48048 | ATP-sensitive inward rectifier potassium channel 1 | Protein |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0006939 | Smooth muscle contraction | BiologicalProcess |
| GO:0045907 | Vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Minoxidil | INCREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 1 |
| Atp-Sensitive Inward Rectifier Potassium Channel 1 | PARTICIPATES IN | Membrane Hyperpolarization |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | CONTRIBUTES TO | Hypertension |
Reference: