Path ID: DB00350_MESH_D000505_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008914 | minoxidil | Drug |
| CL:0000346 | dermal papillary cells | Cell |
| reactome:R-HSA-5684996 | ERK1/ERK2 pathway | Pathway |
| UniProt:P48048 | ATP-sensitive inward rectifier potassium channel 1 | Protein |
| GO:0043066 | negative regulation of apoptotic process | BiologicalProcess |
| CL:0002559 | hair follicle cell | Cell |
| GO:0060081 | membrane hyperpolarization | BiologicalProcess |
| GO:0070509 | transmembrane calcium influx | BiologicalProcess |
| GO:0042311 | vasodilation | BiologicalProcess |
| GO:0008015 | blood circulation | BiologicalProcess |
| GO:0042640 | hair growth | BiologicalProcess |
| MESH:D000505 | androgenic alopecia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Minoxidil | POSITIVELY REGULATES | Erk1/Erk2 Pathway |
| Minoxidil | PRODUCES | Dermal Papillary Cells |
| Minoxidil | POSITIVELY REGULATES | Atp-Sensitive Inward Rectifier Potassium Channel 1 |
| Dermal Papillary Cells | NEGATIVELY CORRELATED WITH | Androgenic Alopecia |
| Erk1/Erk2 Pathway | CONTRIBUTES TO | Negative Regulation Of Apoptotic Process |
| Atp-Sensitive Inward Rectifier Potassium Channel 1 | PARTICIPATES IN | Membrane Hyperpolarization |
| Negative Regulation Of Apoptotic Process | LOCATED IN | Hair Follicle Cell |
| Hair Follicle Cell | AFFECTED BY | Androgenic Alopecia |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | NEGATIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | POSITIVELY REGULATES | Blood Circulation |
| Blood Circulation | POSITIVELY CORRELATED WITH | Hair Growth |
| Hair Growth | NEGATIVELY CORRELATED WITH | Androgenic Alopecia |
Reference: