Path ID: DB00348_MESH_D020176_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C077073 | Nitisinone | Drug |
| UniProt:P32754 | 4-hydroxyphenylpyruvate dioxygenase | Protein |
| GO:0006572 | Tyrosine catabolic process | BiologicalProcess |
| MESH:C105171 | Fumarylacetoacetate | ChemicalSubstance |
| HP:0001394 | Cirrhosis | PhenotypicFeature |
| MESH:D020176 | Tyrosinemia type I | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nitisinone | DECREASES ACTIVITY OF | 4-Hydroxyphenylpyruvate Dioxygenase |
| 4-Hydroxyphenylpyruvate Dioxygenase | POSITIVELY REGULATES | Tyrosine Catabolic Process |
| Tyrosine Catabolic Process | PRODUCES | Fumarylacetoacetate |
| Fumarylacetoacetate | CONTRIBUTES TO | Cirrhosis |
| Cirrhosis | MANIFESTATION OF | Tyrosinemia Type I |
Reference: