Path ID: DB00347_MESH_D004827_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014293 | trimethadione | Drug |
| UniProt:O43497 | Voltage-dependent T-type calcium channel subunit alpha-1G | Protein |
| UniProt:Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | Protein |
| UniProt:O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | Protein |
| GO:0005245 | voltage-gated calcium channel activity | MolecularActivity |
| GO:0014047 | glutamate secretion | BiologicalProcess |
| GO:0014051 | gamma-aminobutyric acid secretion | BiologicalProcess |
| MESH:D004827 | Epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trimethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G |
| Trimethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H |
| Trimethadione | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Gated Calcium Channel Activity | POSITIVELY CORRELATED WITH | Glutamate Secretion |
| Voltage-Gated Calcium Channel Activity | POSITIVELY CORRELATED WITH | Gamma-Aminobutyric Acid Secretion |
| Gamma-Aminobutyric Acid Secretion | POSITIVELY CORRELATED WITH | Epilepsy |
| Glutamate Secretion | POSITIVELY CORRELATED WITH | Epilepsy |
Reference: