Path ID: DB00343_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004110 | diltiazem | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q06432 | Voltage-dependent calcium channel gamma-1 subunit | Protein |
| GO:0060402 | calcium ion transport into cytosol | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Gamma-1 Subunit |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Voltage-Dependent Calcium Channel Gamma-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Calcium Ion Transport Into Cytosol | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
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