Path ID: DB00343_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004110 | diltiazem | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q06432 | Voltage-dependent calcium channel gamma-1 subunit | Protein |
| GO:0061337 | cardiac conduction | BiologicalProcess |
| GO:0060047 | heart contraction | BiologicalProcess |
| HP:0001692 | Atrial arrhythmia | PhenotypicFeature |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Gamma-1 Subunit |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | POSITIVELY REGULATES | Cardiac Conduction |
| Voltage-Dependent Calcium Channel Gamma-1 Subunit | POSITIVELY REGULATES | Cardiac Conduction |
| Cardiac Conduction | POSITIVELY CORRELATED WITH | Heart Contraction |
| Heart Contraction | POSITIVELY CORRELATED WITH | Atrial Arrhythmia |
| Atrial Arrhythmia | MANIFESTATION OF | Atrial Fibrillation |
Reference: