Path ID: DB00343_MESH_D000788_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004110 | diltiazem | Drug |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:Q06432 | Voltage-dependent calcium channel gamma-1 subunit | Protein |
| GO:0060402 | calcium ion transport into cytosol | BiologicalProcess |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| HP:0033401 | Tissue ischemia | PhenotypicFeature |
| MESH:D000788 | Prinzmetal angina | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Diltiazem | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Gamma-1 Subunit |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Voltage-Dependent Calcium Channel Gamma-1 Subunit | POSITIVELY REGULATES | Calcium Ion Transport Into Cytosol |
| Calcium Ion Transport Into Cytosol | POSITIVELY CORRELATED WITH | Vasoconstriction |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Tissue Ischemia |
| Tissue Ischemia | POSITIVELY CORRELATED WITH | Prinzmetal Angina |
Reference: