Path ID: DB00342_MESH_D006255_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016593 | Terfenadine | Drug |
| MESH:C093230 | fexofenadine | ChemicalSubstance |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| MESH:D006632 | Histamine | ChemicalSubstance |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D006255 | Rhinitis, Allergic, Seasonal | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Terfenadine | HAS METABOLITE | Fexofenadine |
| Fexofenadine | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Histamine H1 Receptor | POSITIVELY CORRELATED WITH | Histamine |
| Histamine | POSITIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | CONTRIBUTES TO | Rhinitis, Allergic, Seasonal |
Comment: Terfenadine is a prodrug, which is metabolized and converted into the active form fexofenadine in the liver.
Reference: