Path ID: DB00339_MESH_D014397_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D011718 | Pyrazinamide | Drug |
| MESH:C005296 | Pyrazinoic acid | ChemicalSubstance |
| GO:0005840 | Ribosome | CellularComponent |
| InterPro:IPR003965 | Fatty acid synthase | GeneFamily |
| GO:0006412 | Translation | BiologicalProcess |
| taxonomy:1773 | Mycobacterium tuberculosis | OrganismTaxon |
| GO:0006633 | Fatty acid biosynthetic process | BiologicalProcess |
| MESH:D014397 | Pulmonary tuberculosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pyrazinamide | HAS METABOLITE | Pyrazinoic Acid |
| Pyrazinoic Acid | DECREASES ACTIVITY OF | Ribosome |
| Pyrazinoic Acid | DECREASES ACTIVITY OF | Fatty Acid Synthase |
| Ribosome | POSITIVELY REGULATES | Translation |
| Translation | IN TAXON | Mycobacterium Tuberculosis |
| Fatty Acid Synthase | POSITIVELY REGULATES | Fatty Acid Biosynthetic Process |
| Fatty Acid Biosynthetic Process | IN TAXON | Mycobacterium Tuberculosis |
| Mycobacterium Tuberculosis | CAUSES | Pulmonary Tuberculosis |
Comment: Pyrazinamide diffuses into active M. tuberculosis that express pyrazinamidase enzyme that converts pyrazinamide to the active form pyrazinoic acid.
Reference: