Path ID: DB00331_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008687 | Metformin | Drug |
| UniProt:Q16134 | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | Protein |
| GO:0042775 | Mitochondrial ATP synthesis coupled electron transport | BiologicalProcess |
| GO:0001951 | Intestinal D-glucose absorption | BiologicalProcess |
| MESH:D006943 | Hyperglycemia | Disease |
| GO:0004679 | AMP-activated protein kinase activity | MolecularActivity |
| MESH:D000249 | Adenosine Monophosphate | ChemicalSubstance |
| GO:0042132 | Fructose 1,6-bisphosphate 1-phosphatase activity | MolecularActivity |
| GO:0006094 | Gluconeogenesis | BiologicalProcess |
| MESH:D006943 | Hyperglycemia | Disease |
| GO:0009331 | Glycerol-3-phosphate dehydrogenase complex | CellularComponent |
| GO:0004346 | Glucose-6-phosphatase activity | MolecularActivity |
| InterPro:IPR002441 | Glucose transporter type 4 | GeneFamily |
| GO:0004611 | Phosphoenolpyruvate carboxykinase activity | MolecularActivity |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Metformin | DECREASES ACTIVITY OF | Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase, Mitochondrial |
| Metformin | NEGATIVELY REGULATES | Intestinal D-Glucose Absorption |
| Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase, Mitochondrial | PART OF | Mitochondrial Atp Synthesis Coupled Electron Transport |
| Intestinal D-Glucose Absorption | POSITIVELY CORRELATED WITH | Hyperglycemia |
| Mitochondrial Atp Synthesis Coupled Electron Transport | NEGATIVELY REGULATES | Amp-Activated Protein Kinase Activity |
| Mitochondrial Atp Synthesis Coupled Electron Transport | DECREASES ABUNDANCE OF | Adenosine Monophosphate |
| Amp-Activated Protein Kinase Activity | NEGATIVELY REGULATES | Glucose-6-Phosphatase Activity |
| Adenosine Monophosphate | DECREASES ACTIVITY OF | Fructose 1,6-Bisphosphate 1-Phosphatase Activity |
| Fructose 1,6-Bisphosphate 1-Phosphatase Activity | POSITIVELY REGULATES | Gluconeogenesis |
| Gluconeogenesis | CONTRIBUTES TO | Hyperglycemia |
| Hyperglycemia | MANIFESTATION OF | Diabetes Mellitus Type 2 |
| Amp-Activated Protein Kinase Activity | NEGATIVELY REGULATES | Glycerol-3-Phosphate Dehydrogenase Complex |
| Glucose-6-Phosphatase Activity | POSITIVELY REGULATES | Gluconeogenesis |
| Glycerol-3-Phosphate Dehydrogenase Complex | POSITIVELY REGULATES | Gluconeogenesis |
| Gluconeogenesis | POSITIVELY CORRELATED WITH | Diabetes Mellitus Type 2 |
| Amp-Activated Protein Kinase Activity | INCREASES ACTIVITY OF | Glucose Transporter Type 4 |
| Glucose Transporter Type 4 | NEGATIVELY REGULATES | Hyperglycemia |
| Amp-Activated Protein Kinase Activity | NEGATIVELY REGULATES | Phosphoenolpyruvate Carboxykinase Activity |
| Phosphoenolpyruvate Carboxykinase Activity | POSITIVELY REGULATES | Gluconeogenesis |
| Hyperglycemia | MANIFESTATION OF | Diabetes Mellitus Type 2 |
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