Path ID: DB00327_MESH_D010146_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004091 | Hydromorphone | Drug |
| UniProt:P35372 | Mu-type opioid receptor | Protein |
| reactome:R-HSA-372790 | Signaling by GPCR | Pathway |
| UniProt:B7Z2C7 | Adenylate cyclase | Protein |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| UniProt:Q14654 | ATP-sensitive inward rectifier potassium channel 11 | Protein |
| GO:0070509 | Transmembrane calcium influx | BiologicalProcess |
| GO:0060081 | Membrane hyperpolarization | BiologicalProcess |
| GO:1990793 | Substance P secretion, neurotransmission | BiologicalProcess |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| GO:0099610 | Action potential initiation | BiologicalProcess |
| CL:0000198 | Nociceptor | Cell |
| MESH:D010146 | Pain | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Hydromorphone | INCREASES ACTIVITY OF | Mu-Type Opioid Receptor |
| Mu-Type Opioid Receptor | POSITIVELY REGULATES | Signaling By Gpcr |
| Signaling By Gpcr | DECREASES ACTIVITY OF | Adenylate Cyclase |
| Adenylate Cyclase | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Atp-Sensitive Inward Rectifier Potassium Channel 11 |
| 3’,5’-Cyclic Amp | POSITIVELY CORRELATED WITH | Transmembrane Calcium Influx |
| Atp-Sensitive Inward Rectifier Potassium Channel 11 | PARTICIPATES IN | Membrane Hyperpolarization |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Substance P Secretion, Neurotransmission |
| Transmembrane Calcium Influx | POSITIVELY REGULATES | Glutamate Secretion, Neurotransmission |
| Membrane Hyperpolarization | NEGATIVELY REGULATES | Action Potential Initiation |
| Substance P Secretion, Neurotransmission | LOCATED IN | Nociceptor |
| Glutamate Secretion, Neurotransmission | LOCATED IN | Nociceptor |
| Action Potential Initiation | POSITIVELY REGULATES | Nociceptor |
| Nociceptor | POSITIVELY CORRELATED WITH | Pain |
Reference: