Path ID: DB00325_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009599 | nitroprusside | Drug |
| CHEBI:16480 | nitric oxide | ChemicalSubstance |
| GO:0004383 | guanylate cyclase activity | MolecularActivity |
| MESH:D006152 | cyclic GMP | ChemicalSubstance |
| GO:0044557 | smooth muscle relaxation | BiologicalProcess |
| GO:0042311 | vasodilation | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nitroprusside | PRODUCES | Nitric Oxide |
| Nitric Oxide | POSITIVELY REGULATES | Guanylate Cyclase Activity |
| Guanylate Cyclase Activity | INCREASES ABUNDANCE OF | Cyclic Gmp |
| Cyclic Gmp | POSITIVELY REGULATES | Smooth Muscle Relaxation |
| Smooth Muscle Relaxation | POSITIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | NEGATIVELY REGULATES | Increased Blood Pressure |
| Increased Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: