Path ID: DB00322_MESH_D008113_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D005467 | floxuridine | Drug |
| CHEBI:46345 | 5-fluorouracil | ChemicalSubstance |
| UniProt:P04818 | Thymidylate synthase | Protein |
| GO:0006235 | dTTP biosynthetic process | BiologicalProcess |
| GO:0006231 | dTMP biosynthetic process | BiologicalProcess |
| GO:0006260 | DNA replication | BiologicalProcess |
| HP:0031377 | Abnormal cell proliferation | PhenotypicFeature |
| MESH:D008113 | Liver Neoplasms | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Floxuridine | HAS METABOLITE | 5-Fluorouracil |
| 5-Fluorouracil | DECREASES ACTIVITY OF | Thymidylate Synthase |
| Thymidylate Synthase | POSITIVELY REGULATES | Dttp Biosynthetic Process |
| Thymidylate Synthase | POSITIVELY REGULATES | Dtmp Biosynthetic Process |
| Dtmp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Replication |
| Dttp Biosynthetic Process | POSITIVELY CORRELATED WITH | Dna Replication |
| Dna Replication | PRECEDES | Abnormal Cell Proliferation |
| Abnormal Cell Proliferation | POSITIVELY CORRELATED WITH | Liver Neoplasms |
Comment: This disease is denoted as Malignant neoplasm of liver in the original file as per DrugCentral.
Reference: