Path ID: DB00320_MESH_D008881_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004087 | Dihydroergotamine | Drug |
| UniProt:P28221 | 5-hydroxytryptamine receptor 1D | Protein |
| UniProt:P28222 | 5-hydroxytryptamine receptor 1B | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| GO:1990793 | Substance P secretion, neurotransmission | BiologicalProcess |
| MESH:D010146 | Pain | Disease |
| MESH:D008881 | Migraine | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dihydroergotamine | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1D |
| Dihydroergotamine | INCREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 1B |
| 5-Hydroxytryptamine Receptor 1D | POSITIVELY REGULATES | Vasoconstriction |
| 5-Hydroxytryptamine Receptor 1B | POSITIVELY REGULATES | Vasoconstriction |
| 5-Hydroxytryptamine Receptor 1B | NEGATIVELY REGULATES | Substance P Secretion, Neurotransmission |
| 5-Hydroxytryptamine Receptor 1D | NEGATIVELY REGULATES | Substance P Secretion, Neurotransmission |
| Vasoconstriction | TREATS | Migraine |
| Substance P Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Pain |
| Pain | POSITIVELY CORRELATED WITH | Migraine |
Reference: