Path ID: DB00318_MESH_D020773_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003061 | codeine | Drug |
| MESH:D009020 | morphine | ChemicalSubstance |
| InterPro:IPR001418 | Opioid receptor | GeneFamily |
| GO:0019233 | sensory perception of pain | BiologicalProcess |
| reactome:R-HSA-418594 | G alpha (i) signalling events | Pathway |
| MESH:D013373 | Substance P | ChemicalSubstance |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D020773 | Headache disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Codeine | HAS METABOLITE | Morphine |
| Morphine | INCREASES ACTIVITY OF | Opioid Receptor |
| Opioid Receptor | PARTICIPATES IN | G Alpha (I) Signalling Events |
| G Alpha (I) Signalling Events | DECREASES ABUNDANCE OF | Substance P |
| Substance P | POSITIVELY CORRELATED WITH | Pain |
| Pain | MANIFESTATION OF | Headache Disorder |
| Opioid Receptor | DECREASES ACTIVITY OF | Sensory Perception Of Pain |
| Sensory Perception Of Pain | CORRELATED WITH | Headache Disorder |
Comment: It’s been suggested that for those who suffer from chronic headaches, the long term use of opioids appears to result in greater harm than benefit (https://en.wikipedia.org/wiki/Headache#Management).
Reference: