Path ID: DB00318_MESH_D003371_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003061 | codeine | Drug |
| MESH:D009020 | morphine | ChemicalSubstance |
| InterPro:IPR001418 | Opioid receptor | GeneFamily |
| GO:0060004 | reflex | BiologicalProcess |
| MESH:D003371 | Cough | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Codeine | HAS METABOLITE | Morphine |
| Morphine | INCREASES ACTIVITY OF | Opioid Receptor |
| Opioid Receptor | NEGATIVELY CORRELATED WITH | Reflex |
| Reflex | POSITIVELY CORRELATED WITH | Cough |
Comment: It is believed that the antitussive action of codeine works via stimulation of μ-opioid receptors (https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/003/676/original/Codeine_FDA_label.pdf?1551131944).
Reference: