Path ID: DB00317_MESH_D002289_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C419708 | Gefitinib | Drug |
| UniProt:P00533 | Epidermal growth factor receptor | Protein |
| reactome:R-HSA-5673001 | RAF/MAP kinase cascade | Pathway |
| reactome:R-HSA-109704 | PI3K Cascade | Pathway |
| GO:0008283 | Cell proliferation | BiologicalProcess |
| MESH:D002289 | Non-small cell lung cancer | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Gefitinib | DECREASES ACTIVITY OF | Epidermal Growth Factor Receptor |
| Epidermal Growth Factor Receptor | POSITIVELY REGULATES | Raf/Map Kinase Cascade |
| Epidermal Growth Factor Receptor | POSITIVELY REGULATES | Pi3K Cascade |
| Raf/Map Kinase Cascade | POSITIVELY REGULATES | Cell Proliferation |
| Pi3K Cascade | POSITIVELY REGULATES | Cell Proliferation |
| Cell Proliferation | CAUSES | Non-Small Cell Lung Cancer |
Reference: