Path ID: DB00313_MESH_D001714_5
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014635 | valproic acid | Drug |
| UniProt:P29966 | Myristoylated alanine-rich C kinase substrate | Protein |
| UniProt:Q02156 | protein kinase C (PKC)-ε | Protein |
| GO:0051823 | synaptic remodeling | BiologicalProcess |
| UBERON:0001870 | frontal cortex | GrossAnatomicalStructure |
| MESH:D001714 | Bipolar disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Valproic Acid | NEGATIVELY REGULATES | Myristoylated Alanine-Rich C Kinase Substrate |
| Myristoylated Alanine-Rich C Kinase Substrate | NEGATIVELY REGULATES | Protein Kinase C (Pkc)-Ε |
| Protein Kinase C (Pkc)-Ε | CONTRIBUTES TO | Synaptic Remodeling |
| Synaptic Remodeling | LOCATED IN | Frontal Cortex |
| Frontal Cortex | CORRELATED WITH | Bipolar Disorder |
Reference: