Path ID: DB00310_MESH_D004487_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002752 | Chlortalidone | Drug |
| UniProt:Q13621 | Solute carrier family 12 member 1 | Protein |
| GO:0070294 | Renal sodium ion reabsorption | BiologicalProcess |
| GO:0003092 | Renal water retention | BiologicalProcess |
| HP:0011104 | Abnormality of blood volume homeostasis | PhenotypicFeature |
| MESH:D004487 | Edema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Chlortalidone | DECREASES ACTIVITY OF | Solute Carrier Family 12 Member 1 |
| Solute Carrier Family 12 Member 1 | PARTICIPATES IN | Renal Sodium Ion Reabsorption |
| Renal Sodium Ion Reabsorption | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | CONTRIBUTES TO | Abnormality Of Blood Volume Homeostasis |
| Abnormality Of Blood Volume Homeostasis | CONTRIBUTES TO | Edema |
Reference: