Path ID: DB00300_MESH_D019694_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB00300 | Tenofovir disoproxil | Drug |
| MESH:D000068698 | Tenofovir | ChemicalSubstance |
| MESH:C583447 | tenofovir diphosphate | ChemicalSubstance |
| UniProt:P03156 | Protein P | Protein |
| GO:0071897 | DNA biosynthetic process | BiologicalProcess |
| taxonomy:10407 | Hepatitis B virus | OrganismTaxon |
| MESH:D019694 | Hepatitis B, Chronic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tenofovir Disoproxil | HAS METABOLITE | Tenofovir |
| Tenofovir | HAS ACTIVE INGREDIENT | Tenofovir Diphosphate |
| Tenofovir Diphosphate | DECREASES ACTIVITY OF | Protein P |
| Protein P | POSITIVELY REGULATES | Dna Biosynthetic Process |
| Dna Biosynthetic Process | OCCURS IN | Hepatitis B Virus |
| Hepatitis B Virus | CAUSES | Hepatitis B, Chronic |
Comment: Tenofovir disoproxil acts as a prodrug of tenofovir, which is then converted to the active metabolite, tenofovir diphosphate in the cell.
Reference: