Path ID: DB00300_MESH_D015658_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB00300 | Tenofovir disoproxil | Drug |
| MESH:D000068698 | Tenofovir | ChemicalSubstance |
| MESH:C583447 | tenofovir diphosphate | ChemicalSubstance |
| UniProt:Q72547 | Reverse transcriptase/RNaseH | Protein |
| GO:0001171 | reverse transcription | BiologicalProcess |
| taxonomy:12721 | Human immunodeficiency virus | OrganismTaxon |
| MESH:D015658 | HIV Infections | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tenofovir Disoproxil | HAS METABOLITE | Tenofovir |
| Tenofovir | HAS ACTIVE INGREDIENT | Tenofovir Diphosphate |
| Tenofovir Diphosphate | DECREASES ACTIVITY OF | Reverse Transcriptase/Rnaseh |
| Reverse Transcriptase/Rnaseh | POSITIVELY REGULATES | Reverse Transcription |
| Reverse Transcription | OCCURS IN | Human Immunodeficiency Virus |
| Human Immunodeficiency Virus | CAUSES | Hiv Infections |
Comment: Tenofovir disoproxil acts as a prodrug of tenofovir, which is then converted to the active metabolite, tenofovir diphosphate in the cell.
Reference: