Path ID: DB00287_MESH_D005902_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069557 | Travoprost | Drug |
| UniProt:P43088 | Prostaglandin F2-alpha receptor | Protein |
| GO:0008237 | Metallopeptidase activity | BiologicalProcess |
| GO:0031012 | Extracellular matrix | CellularComponent |
| UBERON:0001796 | Aqueous humor of eyeball | GrossAnatomicalStructure |
| HP:0007906 | Ocular hypertension | PhenotypicFeature |
| MESH:D005902 | Open-angle glaucoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Travoprost | INCREASES ACTIVITY OF | Prostaglandin F2-Alpha Receptor |
| Prostaglandin F2-Alpha Receptor | POSITIVELY REGULATES | Metallopeptidase Activity |
| Metallopeptidase Activity | DECREASES ABUNDANCE OF | Extracellular Matrix |
| Extracellular Matrix | POSITIVELY CORRELATED WITH | Aqueous Humor Of Eyeball |
| Aqueous Humor Of Eyeball | POSITIVELY CORRELATED WITH | Ocular Hypertension |
| Ocular Hypertension | AFFECTS RISK FOR | Open-Angle Glaucoma |
Comment: Travoprost, an isopropyl ester prodrug,that is rapidly hydrolyzed by esterases in the cornea to its biologically active free acid.
Reference: