Path ID: DB00286_MESH_D019584_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004966 | conjugated estrogens | Drug |
| UniProt:P03372 | Estrogen receptor | Protein |
| UniProt:Q92731 | Estrogen receptor beta | Protein |
| GO:0097746 | blood vessel diameter maintenance | BiologicalProcess |
| GO:0006874 | cellular calcium ion homeostasis | BiologicalProcess |
| MESH:D014666 | Vasomotor System | GrossAnatomicalStructure |
| GO:0001659 | temperature homeostasis | BiologicalProcess |
| HP:0005968 | Temperature instability | PhenotypicFeature |
| MESH:D019584 | Menopausal flushing | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Conjugated Estrogens | INCREASES ACTIVITY OF | Estrogen Receptor |
| Conjugated Estrogens | INCREASES ACTIVITY OF | Estrogen Receptor Beta |
| Estrogen Receptor | POSITIVELY REGULATES | Cellular Calcium Ion Homeostasis |
| Estrogen Receptor Beta | REGULATES | Blood Vessel Diameter Maintenance |
| Blood Vessel Diameter Maintenance | CORRELATED WITH | Vasomotor System |
| Cellular Calcium Ion Homeostasis | REGULATES | Vasomotor System |
| Vasomotor System | POSITIVELY REGULATES | Temperature Homeostasis |
| Temperature Homeostasis | NEGATIVELY CORRELATED WITH | Temperature Instability |
| Temperature Instability | POSITIVELY CORRELATED WITH | Menopausal Flushing |
Reference: