Path ID: DB00286_MESH_D004414_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D004966 | conjugated estrogens | Drug |
| UniProt:P03372 | Estrogen receptor | Protein |
| UniProt:Q92731 | Estrogen receptor beta | Protein |
| GO:0071392 | cellular response to estradiol stimulus | BiologicalProcess |
| HP:0031088 | Vaginal dryness | PhenotypicFeature |
| MESH:D004414 | Dyspareunia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Conjugated Estrogens | INCREASES ACTIVITY OF | Estrogen Receptor |
| Conjugated Estrogens | INCREASES ACTIVITY OF | Estrogen Receptor Beta |
| Estrogen Receptor | POSITIVELY REGULATES | Cellular Response To Estradiol Stimulus |
| Estrogen Receptor Beta | POSITIVELY REGULATES | Cellular Response To Estradiol Stimulus |
| Cellular Response To Estradiol Stimulus | NEGATIVELY CORRELATED WITH | Vaginal Dryness |
| Vaginal Dryness | POSITIVELY CORRELATED WITH | Dyspareunia |
Reference: