Path ID: DB00282_MESH_D010001_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C019248 | Pamidronic acid | Drug |
| UniProt:P14324 | Farnesyl pyrophosphate synthase | Protein |
| UniProt:O95749 | Geranylgeranyl pyrophosphate synthase | Protein |
| CHEBI:52255 | Hydroxylapatite | ChemicalSubstance |
| GO:0008299 | Isoprenoid biosynthetic process | BiologicalProcess |
| GO:0001503 | Ossification | BiologicalProcess |
| GO:1990523 | Bone regeneration | BiologicalProcess |
| CL:0000092 | Osteoclast | Cell |
| GO:0045453 | Bone resorption | BiologicalProcess |
| MESH:D010001 | Osteitis deformans | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pamidronic Acid | DECREASES ACTIVITY OF | Farnesyl Pyrophosphate Synthase |
| Pamidronic Acid | DECREASES ACTIVITY OF | Geranylgeranyl Pyrophosphate Synthase |
| Pamidronic Acid | MOLECULARLY INTERACTS WITH | Hydroxylapatite |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Ossification |
| Hydroxylapatite | POSITIVELY CORRELATED WITH | Bone Regeneration |
| Farnesyl Pyrophosphate Synthase | POSITIVELY CORRELATED WITH | Isoprenoid Biosynthetic Process |
| Geranylgeranyl Pyrophosphate Synthase | POSITIVELY CORRELATED WITH | Isoprenoid Biosynthetic Process |
| Isoprenoid Biosynthetic Process | POSITIVELY REGULATES | Osteoclast |
| Osteoclast | POSITIVELY CORRELATED WITH | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Osteitis Deformans |
| Ossification | NEGATIVELY CORRELATED WITH | Osteitis Deformans |
| Bone Regeneration | NEGATIVELY CORRELATED WITH | Osteitis Deformans |
Reference: