Path ID: DB00279_MESH_D003409_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D014284 | Liothyronine | Drug |
| UniProt:P10827 | Thyroid hormone receptor alpha | Protein |
| UniProt:P10828 | Thyroid hormone receptor beta | Protein |
| GO:0002154 | Thyroid hormone mediated signaling pathway | BiologicalProcess |
| HP:0001508 | Failure to thrive | PhenotypicFeature |
| HP:0001252 | Hypotonia | PhenotypicFeature |
| HP:0002045 | Hypothermia | PhenotypicFeature |
| HP:0001249 | Intellectual disability | PhenotypicFeature |
| MESH:D003409 | Congenital hypothyroidism | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Liothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Alpha |
| Liothyronine | INCREASES ACTIVITY OF | Thyroid Hormone Receptor Beta |
| Thyroid Hormone Receptor Alpha | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Receptor Beta | POSITIVELY REGULATES | Thyroid Hormone Mediated Signaling Pathway |
| Thyroid Hormone Mediated Signaling Pathway | NEGATIVELY CORRELATED WITH | Failure To Thrive |
| Thyroid Hormone Mediated Signaling Pathway | NEGATIVELY CORRELATED WITH | Hypotonia |
| Thyroid Hormone Mediated Signaling Pathway | NEGATIVELY CORRELATED WITH | Hypothermia |
| Thyroid Hormone Mediated Signaling Pathway | NEGATIVELY CORRELATED WITH | Intellectual Disability |
| Failure To Thrive | POSITIVELY CORRELATED WITH | Congenital Hypothyroidism |
| Intellectual Disability | POSITIVELY CORRELATED WITH | Congenital Hypothyroidism |
| Hypotonia | POSITIVELY CORRELATED WITH | Congenital Hypothyroidism |
| Hypothermia | POSITIVELY CORRELATED WITH | Congenital Hypothyroidism |
Reference: