Path ID: DB00277_MESH_D011656_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013806 | theophylline | Drug |
| MESH:D018047 | Receptors, Purinergic P1 | GeneFamily |
| MESH:D015106 | 3’,5’-Cyclic-GMP Phosphodiesterases | GeneFamily |
| MESH:D015105 | 3’,5’-Cyclic-AMP Phosphodiesterases | GeneFamily |
| UniProt:Q92769 | Histone deacetylase 2 | Protein |
| GO:0016575 | histone deacetylation | BiologicalProcess |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| GO:0019933 | cAMP-mediated signaling | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| MESH:D011656 | Pulmonary emphysema | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Theophylline | INCREASES ACTIVITY OF | Histone Deacetylase 2 |
| Histone Deacetylase 2 | POSITIVELY REGULATES | Histone Deacetylation |
| Histone Deacetylation | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Theophylline | DECREASES ACTIVITY OF | 3’,5’-Cyclic-Amp Phosphodiesterases |
| Theophylline | DECREASES ACTIVITY OF | 3’,5’-Cyclic-Gmp Phosphodiesterases |
| Theophylline | DECREASES ACTIVITY OF | Receptors, Purinergic P1 |
| 3’,5’-Cyclic-Amp Phosphodiesterases | POSITIVELY REGULATES | Camp Catabolic Process |
| 3’,5’-Cyclic-Gmp Phosphodiesterases | NEGATIVELY REGULATES | Camp-Mediated Signaling |
| Receptors, Purinergic P1 | POSITIVELY REGULATES | Inflammatory Response |
| Camp Catabolic Process | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| Camp-Mediated Signaling | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Pulmonary Emphysema |
Reference: