Path ID: DB00277_MESH_D008171_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013806 | theophylline | Drug |
| InterPro:IPR001634 | Adenosine receptor | GeneFamily |
| InterPro:IPR023174 | 3’5’-cyclic nucleotide phosphodiesterase, conserved site | GeneFamily |
| UniProt:Q92769 | Histone deacetylase 2 | Protein |
| GO:0016575 | histone deacetylation | BiologicalProcess |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| GO:0019933 | cAMP-mediated signaling | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0044557 | relaxation of smooth muscle | BiologicalProcess |
| HP:4000007 | Bronchoconstriction | PhenotypicFeature |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| MESH:D008171 | Lung Diseases | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Theophylline | INCREASES ACTIVITY OF | Histone Deacetylase 2 |
| Histone Deacetylase 2 | POSITIVELY REGULATES | Histone Deacetylation |
| Histone Deacetylation | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Theophylline | DECREASES ACTIVITY OF | 3’5’-Cyclic Nucleotide Phosphodiesterase, Conserved Site |
| Theophylline | DECREASES ACTIVITY OF | Adenosine Receptor |
| 3’5’-Cyclic Nucleotide Phosphodiesterase, Conserved Site | POSITIVELY REGULATES | Camp Catabolic Process |
| 3’5’-Cyclic Nucleotide Phosphodiesterase, Conserved Site | NEGATIVELY REGULATES | Camp-Mediated Signaling |
| Adenosine Receptor | POSITIVELY REGULATES | Bronchoconstriction |
| Bronchoconstriction | POSITIVELY CORRELATED WITH | Lung Diseases |
| Adenosine Receptor | POSITIVELY REGULATES | Inflammatory Response |
| Camp Catabolic Process | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| Camp-Mediated Signaling | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | POSITIVELY CORRELATED WITH | Relaxation Of Smooth Muscle |
| 3’,5’-Cyclic Amp | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Lung Diseases |
| Relaxation Of Smooth Muscle | NEGATIVELY CORRELATED WITH | Lung Diseases |
Comment: This disease is also known as Disorder of lung as per DrugCentral. Note this disease name is a very generic term, that could encompass any diseases of the lungs, including neoplasms, infectious diseases (e.g. tuberculosis) and rare diseases (e.g. cystic fibrosis) for which theophylline may not have any therapeutic benefit at all. Therefore, this annotation is done for all lung diseases that could be indications for this drug to encompass diseases that are similar to asthma, bronchitis, COPD and alike.
Reference: