Path ID: DB00277_MESH_D000080445_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013806 | theophylline | Drug |
| MESH:D018047 | Receptors, Purinergic P1 | GeneFamily |
| MESH:D015106 | 3’,5’-Cyclic-GMP Phosphodiesterases | GeneFamily |
| MESH:D015105 | 3’,5’-Cyclic-AMP Phosphodiesterases | GeneFamily |
| UniProt:Q92769 | Histone deacetylase 2 | Protein |
| GO:0016575 | histone deacetylation | BiologicalProcess |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| GO:0019933 | cAMP-mediated signaling | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| GO:0044557 | relaxation of smooth muscle | BiologicalProcess |
| MESH:D016084 | Bronchoconstriction | BiologicalProcess |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| MESH:D000080445 | Asthma-chronic obstructive pulmonary disease overlap syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Theophylline | INCREASES ACTIVITY OF | Histone Deacetylase 2 |
| Histone Deacetylase 2 | POSITIVELY REGULATES | Histone Deacetylation |
| Histone Deacetylation | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Theophylline | DECREASES ACTIVITY OF | 3’,5’-Cyclic-Amp Phosphodiesterases |
| Theophylline | DECREASES ACTIVITY OF | 3’,5’-Cyclic-Gmp Phosphodiesterases |
| Theophylline | DECREASES ACTIVITY OF | Receptors, Purinergic P1 |
| 3’,5’-Cyclic-Amp Phosphodiesterases | POSITIVELY REGULATES | Camp Catabolic Process |
| 3’,5’-Cyclic-Gmp Phosphodiesterases | NEGATIVELY REGULATES | Camp-Mediated Signaling |
| Receptors, Purinergic P1 | POSITIVELY REGULATES | Bronchoconstriction |
| Bronchoconstriction | POSITIVELY CORRELATED WITH | Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome |
| Receptors, Purinergic P1 | POSITIVELY REGULATES | Inflammatory Response |
| Camp Catabolic Process | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| Camp-Mediated Signaling | INCREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | POSITIVELY CORRELATED WITH | Relaxation Of Smooth Muscle |
| 3’,5’-Cyclic Amp | NEGATIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome |
| Relaxation Of Smooth Muscle | NEGATIVELY CORRELATED WITH | Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome |
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