Path ID: DB00275_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068557 | Olmesartan Medoxomil | Drug |
| MESH:C437965 | olmesartan | ChemicalSubstance |
| UniProt:P30556 | Type-1 angiotensin II receptor | Protein |
| GO:0042310 | vasoconstriction | BiologicalProcess |
| GO:0002018 | renin-angiotensin regulation of aldosterone production | BiologicalProcess |
| GO:0003092 | renal water retention | BiologicalProcess |
| GO:0070294 | renal sodium ion absorption | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Olmesartan Medoxomil | HAS METABOLITE | Olmesartan |
| Olmesartan | NEGATIVELY REGULATES | Type-1 Angiotensin Ii Receptor |
| Type-1 Angiotensin Ii Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Type-1 Angiotensin Ii Receptor | POSITIVELY REGULATES | Renin-Angiotensin Regulation Of Aldosterone Production |
| Renin-Angiotensin Regulation Of Aldosterone Production | POSITIVELY REGULATES | Renal Water Retention |
| Renin-Angiotensin Regulation Of Aldosterone Production | POSITIVELY REGULATES | Renal Sodium Ion Absorption |
| Renal Sodium Ion Absorption | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Renal Water Retention | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Vasoconstriction | POSITIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertensive Disorder |
Reference: