Path ID: DB00273_MESH_D065768_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000077236 | topiramate | Drug |
| GO:0022851 | GABA-gated chloride ion channel activity | MolecularActivity |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| GO:0051899 | membrane depolarization | BiologicalProcess |
| GO:0019228 | neuronal action potential | BiologicalProcess |
| GO:0050806 | positive regulation of synaptic transmission | BiologicalProcess |
| MESH:D065768 | Lennox Gastaut Syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Topiramate | INCREASES ACTIVITY OF | Gaba-Gated Chloride Ion Channel Activity |
| Topiramate | DECREASES ACTIVITY OF | Voltage Gated Sodium Channel, Alpha Subunit |
| Gaba-Gated Chloride Ion Channel Activity | NEGATIVELY CORRELATED WITH | Membrane Depolarization |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY CORRELATED WITH | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Neuronal Action Potential |
| Neuronal Action Potential | REGULATES | Positive Regulation Of Synaptic Transmission |
| Positive Regulation Of Synaptic Transmission | POSITIVELY CORRELATED WITH | Lennox Gastaut Syndrome |
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