Path ID: DB00270_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017275 | Isradipine | Drug |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| InterPro:IPR000584 | Voltage-dependent L-type calcium channel subunit beta | GeneFamily |
| InterPro:IPR013680 | Voltage-dependent calcium channel, alpha-2/delta subunit, conserved regio | GeneFamily |
| UniProt:O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | Protein |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0004687 | Myosin light chain kinase activity | BiologicalProcess |
| GO:0006939 | Smooth muscle contraction | BiologicalProcess |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Isradipine | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Isradipine | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Beta |
| Isradipine | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel, Alpha-2/Delta Subunit, Conserved Regio |
| Isradipine | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Calcium Ion Import |
| Voltage-Dependent L-Type Calcium Channel Subunit Beta | POSITIVELY REGULATES | Calcium Ion Import |
| Voltage-Dependent Calcium Channel, Alpha-2/Delta Subunit, Conserved Regio | POSITIVELY REGULATES | Calcium Ion Import |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY REGULATES | Myosin Light Chain Kinase Activity |
| Myosin Light Chain Kinase Activity | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | AFFECTS RISK FOR | Hypertensive Disorder |
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