Path ID: DB00268_MESH_D012148_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C046649 | Ropinirole | Drug |
| UniProt:P14416 | Dopamine D2 receptor | Protein |
| UniProt:P35462 | Dopamine D3 receptor | Protein |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| MESH:D012148 | Restless legs | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ropinirole | POSITIVELY REGULATES | Dopamine D2 Receptor |
| Ropinirole | POSITIVELY REGULATES | Dopamine D3 Receptor |
| Dopamine D2 Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| Dopamine D3 Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| Dopamine | PARTICIPATES IN | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | DISRUPTED BY | Restless Legs |
Comment: The precise mechanism of action of ropinirole as a treatment for Restless Legs Syndrome is unknown, however, it is believed to be related to its ability to stimulate dopamine receptors
Reference: