Path ID: DB00261_MESH_D013920_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C021139 | Anagrelid | Drug |
| GO:0035855 | Megakaryocyte development | BiologicalProcess |
| GO:0030220 | Platelet formation | BiologicalProcess |
| HP:0001894 | Thrombocytosis | PhenotypicFeature |
| MESH:D013920 | Essential thrombocythemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Anagrelid | NEGATIVELY REGULATES | Megakaryocyte Development |
| Megakaryocyte Development | POSITIVELY CORRELATED WITH | Platelet Formation |
| Platelet Formation | POSITIVELY CORRELATED WITH | Thrombocytosis |
| Thrombocytosis | MANIFESTATION OF | Essential Thrombocythemia |
Comment: the exact mechanism by which anagrelide lowers platelet count is unclear
Reference: