Path ID: DB00257_MESH_D013281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D013455 | sulfur | Drug |
| CHEBI:16136 | hydrogen sulfide | ChemicalSubstance |
| MESH:D000900 | Anti-Bacterial Agents | Drug |
| taxonomy:210 | Helicobacter pylori | OrganismTaxon |
| MESH:D013281 | Stomatitis, Aphthous | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sulfur | PRECEDES | Hydrogen Sulfide |
| Hydrogen Sulfide | SUBCLASS OF | Anti-Bacterial Agents |
| Anti-Bacterial Agents | DISRUPTS | Helicobacter Pylori |
| Helicobacter Pylori | CAUSES | Stomatitis, Aphthous |
Comment: The disease is denoted as Aphthous ulcer of mouth in the original file but the name used for the path is the one seen in the MESH website. The causes for this disease are not well known (https://ada.com/conditions/aphthous-ulcers/#causes). It’s important to prevent secondary infection of the ulcers (https://en.wikipedia.org/wiki/Aphthous_stomatitis#Medication); that’s when anti-bacterial agents can be administered.
Reference:
- https://go.drugbank.com/drugs/DB09353#mechanism-of-action
- https://ada.com/conditions/aphthous-ulcers/#causes
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441245/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002348/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227248/
- https://www.mayoclinic.org/diseases-conditions/canker-sore/symptoms-causes/syc-20370615