Path ID: DB00257_MESH_D002181_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003022 | clotrimazole | Drug |
| UniProt:P10613 | Lanosterol 14-alpha demethylase | Protein |
| GO:0006696 | ergosterol biosynthetic process | BiologicalProcess |
| CHEBI:16933 | ergosterol | ChemicalSubstance |
| GO:0030445 | yeast-form cell wall | CellularComponent |
| MESH:D002463 | Cell Membrane Permeability | PhenotypicFeature |
| taxonomy:237561 | Candida albicans SC5314 | OrganismTaxon |
| MESH:D002181 | Candidiasis, Vulvovaginal | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Clotrimazole | NEGATIVELY REGULATES | Lanosterol 14-Alpha Demethylase |
| Lanosterol 14-Alpha Demethylase | POSITIVELY REGULATES | Ergosterol Biosynthetic Process |
| Ergosterol Biosynthetic Process | PRODUCES | Ergosterol |
| Ergosterol | LOCATED IN | Yeast-Form Cell Wall |
| Yeast-Form Cell Wall | REGULATES | Cell Membrane Permeability |
| Cell Membrane Permeability | IN TAXON | Candida Albicans Sc5314 |
| Candida Albicans Sc5314 | CAUSES | Candidiasis, Vulvovaginal |
Comment: This drug is fungistatic at concetrations up to 20 mcg/mL, and is fungicidal in vitro when used at higher concentrations. Also please note that MESH:D002181 was initially denoted as Candidal vulvovaginitis in the original xls file but the name on the MESH website, which is Candidiasis, Vulvovaginal, is the one used here for our annotation.
Reference: