Path ID: DB00242_MESH_D020529_1

db00242-mesh-d020529-1

Concepts

Identifier Name Type
MESH:D017338 Cladribine Drug
CHEBI:172731 2-Chloro-2’-deoxyadenosine-5’-triphosphate ChemicalSubstance
UniProt:P23921 Ribonucleoside-diphosphate reductase large subunit Protein
UniProt:Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B Protein
UniProt:P31350 Ribonucleoside-diphosphate reductase subunit M2 Protein
UniProt:P09884 DNA polymerase alpha catalytic subunit Protein
UniProt:P56282 DNA polymerase epsilon subunit 2 Protein
UniProt:Q9NRF9 DNA polymerase epsilon subunit 3 Protein
UniProt:Q9NR33 DNA polymerase epsilon subunit 4 Protein
GO:0006260 DNA replication BiologicalProcess
GO:0046651 Lymphocyte proliferation BiologicalProcess
MESH:D004247 DNA ChemicalSubstance
MESH:D020529 Relapsing remitting multiple sclerosis Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Cladribine HAS METABOLITE 2-Chloro-2’-Deoxyadenosine-5’-Triphosphate
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Ribonucleoside-Diphosphate Reductase Large Subunit
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Ribonucleoside-Diphosphate Reductase Subunit M2 B
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Ribonucleoside-Diphosphate Reductase Subunit M2
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Dna Polymerase Alpha Catalytic Subunit
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Dna Polymerase Epsilon Subunit 2
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Dna Polymerase Epsilon Subunit 3
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DECREASES ACTIVITY OF Dna Polymerase Epsilon Subunit 4
2-Chloro-2’-Deoxyadenosine-5’-Triphosphate DISRUPTS Dna
Ribonucleoside-Diphosphate Reductase Subunit M2 POSITIVELY CORRELATED WITH Dna Replication
Ribonucleoside-Diphosphate Reductase Large Subunit POSITIVELY CORRELATED WITH Dna Replication
Ribonucleoside-Diphosphate Reductase Subunit M2 B POSITIVELY CORRELATED WITH Dna Replication
Dna Polymerase Alpha Catalytic Subunit POSITIVELY CORRELATED WITH Dna Replication
Dna Polymerase Epsilon Subunit 2 POSITIVELY CORRELATED WITH Dna Replication
Dna Polymerase Epsilon Subunit 3 POSITIVELY CORRELATED WITH Dna Replication
Dna Polymerase Epsilon Subunit 4 POSITIVELY CORRELATED WITH Dna Replication
Dna Replication PRECEDES Lymphocyte Proliferation
Dna PARTICIPATES IN Dna Replication
Lymphocyte Proliferation OCCURS IN Relapsing Remitting Multiple Sclerosis

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