Path ID: DB00240_MESH_D001172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069283 | rituximab | Drug |
| UniProt:P11836 | B-lymphocyte antigen CD20 | Protein |
| GO:0006959 | humoral immune response | BiologicalProcess |
| GO:0001788 | antibody-dependent cellular cytotoxicity | BiologicalProcess |
| GO:0097278 | complement-dependent cytotoxicity | BiologicalProcess |
| MESH:D001172 | Rheumatoid arthritis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Rituximab | MOLECULARLY INTERACTS WITH | B-Lymphocyte Antigen Cd20 |
| B-Lymphocyte Antigen Cd20 | REGULATES | Humoral Immune Response |
| Humoral Immune Response | CORRELATED WITH | Antibody-Dependent Cellular Cytotoxicity |
| Humoral Immune Response | CORRELATED WITH | Complement-Dependent Cytotoxicity |
| Antibody-Dependent Cellular Cytotoxicity | NEGATIVELY CORRELATED WITH | Rheumatoid Arthritis |
| Complement-Dependent Cytotoxicity | NEGATIVELY CORRELATED WITH | Rheumatoid Arthritis |
Reference: