Path ID: DB00234_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C074679 | reboxetine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | norepinephrine uptake | BiologicalProcess |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Reboxetine | NEGATIVELY REGULATES | Sodium-Dependent Noradrenaline Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
Comment: MESH:D003865 is denoted as Depressive Disorder, Major in the MESH website. Note that the drug may slighlty inhibit the reuptake of serotonin too.
Reference: