Path ID: DB00232_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008736 | Methylclothiazide | Drug |
| UniProt:P55017 | Solute carrier family 12 member 3 | Protein |
| GO:0070294 | Renal sodium ion absorption | BiologicalProcess |
| GO:0003092 | Renal water retention | BiologicalProcess |
| HP:0011104 | Abnormality of blood volume homeostasis | PhenotypicFeature |
| GO:0045777 | Up regulation of blood pressure | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Methylclothiazide | DECREASES ACTIVITY OF | Solute Carrier Family 12 Member 3 |
| Solute Carrier Family 12 Member 3 | PARTICIPATES IN | Renal Sodium Ion Absorption |
| Renal Sodium Ion Absorption | POSITIVELY CORRELATED WITH | Renal Water Retention |
| Renal Water Retention | CONTRIBUTES TO | Abnormality Of Blood Volume Homeostasis |
| Abnormality Of Blood Volume Homeostasis | CONTRIBUTES TO | Up Regulation Of Blood Pressure |
| Up Regulation Of Blood Pressure | AFFECTS RISK FOR | Hypertensive Disorder |
Comment: The antihypertensive mechanism of methyclothiazide is not well understood.
Reference: