Path ID: DB00230_MESH_D005356_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069583 | Pregabalin | Drug |
| UniProt:P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | Protein |
| GO:0061535 | Glutamate secretion, neurotransmission | BiologicalProcess |
| GO:1990793 | Substance P secretion, neurotransmission | BiologicalProcess |
| GO:0019233 | Sensory perception of pain | BiologicalProcess |
| MESH:D005356 | Fibromyalgia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Pregabalin | DECREASES ACTIVITY OF | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 |
| Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 | POSITIVELY REGULATES | Glutamate Secretion, Neurotransmission |
| Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-1 | POSITIVELY REGULATES | Substance P Secretion, Neurotransmission |
| Glutamate Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Sensory Perception Of Pain |
| Substance P Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Sensory Perception Of Pain |
| Sensory Perception Of Pain | POSITIVELY CORRELATED WITH | Fibromyalgia |
Reference: