Path ID: DB00227_MESH_D052456_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008148 | lovastatin | Drug |
| DB:DBMET01698 | 6’beta-Hydroxylovastatin | ChemicalSubstance |
| UniProt:P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Protein |
| GO:0008610 | lipid biosynthetic process | BiologicalProcess |
| GO:0008654 | phospholipid biosynthetic process | BiologicalProcess |
| MESH:D008075 | Lipoproteins, HDL | ChemicalSubstance |
| MESH:D052456 | Hypoalphalipoproteinemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lovastatin | HAS METABOLITE | 6’Beta-Hydroxylovastatin |
| 6’Beta-Hydroxylovastatin | DECREASES ACTIVITY OF | 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase |
| 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase | POSITIVELY REGULATES | Lipid Biosynthetic Process |
| Lipid Biosynthetic Process | CORRELATED WITH | Phospholipid Biosynthetic Process |
| Phospholipid Biosynthetic Process | INCREASES ABUNDANCE OF | Lipoproteins, Hdl |
| Lipoproteins, Hdl | POSITIVELY CORRELATED WITH | Hypoalphalipoproteinemia |
Reference: