Path ID: DB00211_MESH_D007024_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008879 | Midodrine | Drug |
| CHEBI:73248 | Deglymidodrine | ChemicalSubstance |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| GO:0006939 | Smooth muscle contraction | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D007024 | Orthostatic hypotension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Midodrine | HAS METABOLITE | Deglymidodrine |
| Deglymidodrine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Deglymidodrine | INCREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Alpha-1B Adrenergic Receptor | POSITIVELY REGULATES | Smooth Muscle Contraction |
| Smooth Muscle Contraction | POSITIVELY REGULATES | Increased Blood Pressure |
| Increased Blood Pressure | NEGATIVELY CORRELATED WITH | Orthostatic Hypotension |
Comment: Midodrine is a prodrug, i.e., the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine
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