Path ID: DB00204_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C063533 | dofetilide | Drug |
| UniProt:Q12809 | Potassium voltage-gated channel subfamily H member 2 | Protein |
| UniProt:O95069 | Potassium channel subfamily K member 2 | Protein |
| UniProt:Q14500 | ATP-sensitive inward rectifier potassium channel 12 | Protein |
| GO:0030322 | stabilization of membrane potential | BiologicalProcess |
| GO:0061337 | cardiac conduction | BiologicalProcess |
| reactome:R-HSA-5576890 | Phase 3 - rapid repolarisation | Pathway |
| MESH:D012032 | Refractory Period, Electrophysiological | BiologicalProcess |
| HP:0001692 | Atrial arrhythmia | PhenotypicFeature |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dofetilide | NEGATIVELY REGULATES | Potassium Voltage-Gated Channel Subfamily H Member 2 |
| Dofetilide | NEGATIVELY REGULATES | Potassium Channel Subfamily K Member 2 |
| Dofetilide | NEGATIVELY REGULATES | Atp-Sensitive Inward Rectifier Potassium Channel 12 |
| Potassium Voltage-Gated Channel Subfamily H Member 2 | PARTICIPATES IN | Phase 3 - Rapid Repolarisation |
| Potassium Channel Subfamily K Member 2 | REGULATES | Stabilization Of Membrane Potential |
| Atp-Sensitive Inward Rectifier Potassium Channel 12 | POSITIVELY REGULATES | Cardiac Conduction |
| Phase 3 - Rapid Repolarisation | NEGATIVELY CORRELATED WITH | Refractory Period, Electrophysiological |
| Stabilization Of Membrane Potential | NEGATIVELY CORRELATED WITH | Refractory Period, Electrophysiological |
| Cardiac Conduction | NEGATIVELY CORRELATED WITH | Refractory Period, Electrophysiological |
| Refractory Period, Electrophysiological | NEGATIVELY CORRELATED WITH | Atrial Arrhythmia |
| Atrial Arrhythmia | MANIFESTATION OF | Atrial Fibrillation |
Reference: