Path ID: DB00203_MESH_D000081029_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068677 | Sildenafil | Drug |
| UniProt:O76074 | cGMP-specific 3’,5’-cyclic phosphodiesterase | Protein |
| CHEBI:16356 | 3’,5’-cyclic GMP | ChemicalSubstance |
| GO:0044557 | Relaxation of smooth muscle | BiologicalProcess |
| GO:0042311 | Vasodilation | BiologicalProcess |
| GO:0008217 | Blood pressure | BiologicalProcess |
| MESH:D000081029 | Pulmonary arterial hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sildenafil | DECREASES ACTIVITY OF | Cgmp-Specific 3’,5’-Cyclic Phosphodiesterase |
| Cgmp-Specific 3’,5’-Cyclic Phosphodiesterase | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Gmp |
| 3’,5’-Cyclic Gmp | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Relaxation Of Smooth Muscle | POSITIVELY CORRELATED WITH | Vasodilation |
| Vasodilation | NEGATIVELY REGULATES | Blood Pressure |
| Blood Pressure | POSITIVELY CORRELATED WITH | Pulmonary Arterial Hypertension |
Reference: