Path ID: DB00201_MESH_D065631_1

Concepts
Identifier | Name | Type |
---|---|---|
MESH:D002110 | caffeine | Drug |
InterPro:IPR001634 | Adenosine receptor | GeneFamily |
InterPro:IPR023088 | 3’5’-cyclic nucleotide phosphodiesterase | GeneFamily |
GO:0006198 | cAMP catabolic process | BiologicalProcess |
MESH:D000242 | Cyclic AMP | ChemicalSubstance |
GO:0006954 | inflammatory response | BiologicalProcess |
HP:0001742 | Nasal congestion | PhenotypicFeature |
MESH:D065631 | Rhinitis, Allergic | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
Subject | Predicate | Object |
---|---|---|
Caffeine | DECREASES ACTIVITY OF | Adenosine Receptor |
Caffeine | DECREASES ACTIVITY OF | 3’5’-Cyclic Nucleotide Phosphodiesterase |
Adenosine Receptor | POSITIVELY REGULATES | Inflammatory Response |
3’5’-Cyclic Nucleotide Phosphodiesterase | POSITIVELY REGULATES | Camp Catabolic Process |
Camp Catabolic Process | DECREASES ABUNDANCE OF | Cyclic Amp |
Cyclic Amp | NEGATIVELY CORRELATED WITH | Inflammatory Response |
Inflammatory Response | POSITIVELY CORRELATED WITH | Nasal Congestion |
Nasal Congestion | CONTRIBUTES TO | Rhinitis, Allergic |
Reference:
- https://go.drugbank.com/drugs/DB00201#mechanism-of-action
- https://en.wikipedia.org/wiki/Caffeine
- https://en.wikipedia.org/wiki/Adenosine_receptor
- https://en.wikipedia.org/wiki/Cyclic_nucleotide_phosphodiesterase
- https://pubmed.ncbi.nlm.nih.gov/17397885/
- https://en.wikipedia.org/wiki/Allergic_rhinitis